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Drug-Drug Interaction Primer: A Compendium of Case Vignettes for the Practicing Clinician
By Neil B., M.d. Sandson

• Publisher: American Psychiatric Publishing
• Number Of Pages: 408
• Publication Date: 2007-06-05
• ISBN-10 / ASIN: 1585623059
• ISBN-13 / EAN: 9781585623051
• Binding: Paperback

Product Description:

This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating even entertaining approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient's trimethoprim- sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity.


An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction( s) occurred, and each derives from sound clinical evidence not merely extrapolations from drug characteristics to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book's other features:

• Reorganization by medical subspecialty psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology better facilitates clinical application.
• Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein.
• DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins.
• Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed.

These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner' s skills.

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MEDfacts POCKET GUIDE OF DRUG INTERACTIONS

By: George R. Bailie,Curtis A. Johnson,
Nancy A.Mason and Wendy L. St. Peter.

These drug interaction guidelines are offered as a general summary of information for physicians, pharmacists, nurses and other health professionals. Inappropriate administration of interacting drugs to patients can result in severe injury or death. These guidelines cannot identify medical risks specific to an
individual patient or recommend patient treatment. These guidelines are not to be used as a substitute for professional training. The absence of typographical errors is not guaranteed. These guidelines are not necessarily all-inclusive. Use of these guidelines indicates acknowledgement that neither Nephrology Pharmacy Associates, Inc. (NPA), Bone Care International, Inc. nor the authors will be responsible for any loss or injury, including death, sustained in connection with, or as a result of, the use of these guidelines. Readers should consult the complete information available in the package insert for each agent indicated before prescribing medications. Guides such as this one can only draw from information available at the time of publication. Nephrology Pharmacy Associates, Inc., Bone Care International, Inc. and the authors of these guidelines are under no obligation to update information obtained herein. Future medical advances or product information may affect or change the information provided. Health professionals using these guidelines are responsible for monitoring ongoing medical advances related to
drug therapy

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By Karen Baxter, Mildred Davis, Samuel Driver, Rebecca E. Garner, C. Rhoda Lee

• Publisher: Pharmaceutical Press
• Number Of Pages: 459
• Publication Date: 2009-02-20
• ISBN-10 / ASIN: 0853697957
• ISBN-13 / EAN: 9780853697954

Yang satu ini wajib punya kalo perlu hapal luar kepala. Sudah menjadi tanggung jawab apoteker dalam hal skrining resep pasien, agar tidak terjadi ADR atau permasalahan polifarmasi yang menimbulkan interaksi obat, yang akibatnya berbahaya bagi pasien. Niatnya mau sembuh malah tambah parah sakitnya. Hayo bisa dituntut lo berdasarkan UU yang baru.

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